SYNTHESIS OF DIAMINO ACIDS - POTENTIAL LIPOPOLYSACCHARIDE ANTAGONISTS

被引：4

作者：

BULUSU, MARC

WALDSTATTEN, P

机构：

[1] Sandoz Forschungsinstitut, A-1235 Vienna

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 14期

关键词：

SEPTIC SHOCK; LIPOPOLYSACCHARIDES; ANTAGONISTS; DIAMINO GLUCOSE; DIAMINO ACIDS;

D O I：

10.1016/S0040-4039(00)74161-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,4,6-Tri-O-acetyl-2,3-bis(tert-butyloxycarbonamido)-2,3-dideoxy-alpha-D-glucopyranose (8) was prepared through catalytic reduction and in situ tert-butyloxycorbonylation of 1,4,6-tri-O-acetyl-2-azido-2,3-dideoxy-3-nitro-alpha-D-glucopyra?? nose (5). Starting from 8, 4S,5S-bis(3R-hydroxytetradecanamido)octan-1,8-dioic acid (4) was synthesised in a series of steps.

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页码：1859 / 1862

页数：4

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