SIMIAN IMMUNODEFICIENCY VIRUS SIVMAC CHIMERIC VIRUS WHOSE ENV GENE WAS DERIVED FROM SIV-ENCEPHALITIC BRAIN IS MACROPHAGE-TROPIC BUT NOT NEUROVIRULENT

被引：33

作者：

JOAG, SV

STEPHENS, EB

GALBREATH, D

ZHU, GW

LI, Z

FORESMAN, L

ZHAO, LJ

PINSON, DM

NARAYAN, O

机构：

[1] UNIV KANSAS,MED CTR,ANIM RESOURCES LAB,KANSAS CITY,KS 66160

[2] UNIV KANSAS,MED CTR,DEPT PATHOL & LAB MED,KANSAS CITY,KS 66160

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 02期

关键词：

D O I：

10.1128/JVI.69.2.1367-1369.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We inoculated four rhesus macaques with molecularly cloned simian immunodeficiency virus SIV(mac)239/17E env, a chimeric virus whose env gene was derived from the brain of an SIV-encephalitic macaque. Blood and lymphoid tissues had high frequencies of infected cells. The virus was neuroinvasive, but productive virus replication did not occur in the brain, and animals did not develop encephalitis.

引用

收藏

页码：1367 / 1369

页数：3

相关论文

共 16 条

[1] ANALYSIS OF ENVELOPE CHANGES ACQUIRED BY SIV(MAC)239 DURING NEUROADAPTATION IN RHESUS MACAQUES [J].

ANDERSON, MG ;

HAUER, D ;

SHARMA, DP ;

JOAG, SV ;

NARAYAN, O ;

ZINK, MC ;

CLEMENTS, JE .

VIROLOGY, 1993, 195 (02) :616-626

[2]

BASKIN GB, 1992, J MED PRIMATOL, V21, P59

[3] THE SIMIAN IMMUNODEFICIENCY VIRUSES [J].

DESROSIERS, RC .

ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 :557-578

[4] INTRACEREBRAL INFUSION OF TNF-ALPHA AND IL-6 FAILED TO ACTIVATE LATENT SIV INFECTION IN THE BRAINS OF MACAQUES INOCULATED WITH MACROPHAGE-TROPIC NEUROADAPTED SIVMAC [J].

JOAG, SV ;

ADAMS, RJ ;

PINSON, DM ;

ADANY, I ;

NARAYAN, O .

JOURNAL OF LEUKOCYTE BIOLOGY, 1994, 56 (03) :353-357

[5] EARLY ACTIVATION OF PBMC AND APPEARANCE OF ANTIVIRAL CD8+ CELLS INFLUENCE THE PROGNOSIS OF SIV-INDUCED DISEASE IN RHESUS MACAQUES [J].

JOAG, SV ;

ADAMS, RJ ;

FORESMAN, L ;

GALBREATH, D ;

ZINK, MC ;

PINSON, DM ;

MCCLURE, H ;

NARAYAN, O .

JOURNAL OF MEDICAL PRIMATOLOGY, 1994, 23 (2-3) :108-116

[6] PATHOGENESIS OF SIVMAC INFECTION IN CHINESE AND INDIAN RHESUS MACAQUES - EFFECTS OF SPLENECTOMY ON VIRUS BURDEN [J].

JOAG, SV ;

STEPHENS, EB ;

ADAMS, RJ ;

FORESMAN, L ;

NARAYAN, O .

VIROLOGY, 1994, 200 (02) :436-446

[7] ANTIGENIC VARIATION OF MOLECULARLY CLONED SIV(MAC)239 DURING PERSISTENT INFECTION IN A RHESUS MACAQUE [J].

JOAG, SV ;

ANDERSON, MG ;

CLEMENTS, JE ;

MCENTEE, MF ;

SHARMA, DP ;

ADAMS, RJ ;

NARAYAN, O .

VIROLOGY, 1993, 195 (02) :406-412

[8] INDUCTION OF AIDS IN RHESUS-MONKEYS BY MOLECULARLY CLONED SIMIAN IMMUNODEFICIENCY VIRUS [J].

KESTLER, H ;

KODAMA, T ;

RINGLER, D ;

MARTHAS, M ;

PEDERSEN, N ;

LACKNER, A ;

REGIER, D ;

SEHGAL, P ;

DANIEL, M ;

KING, N ;

DESROSIERS, R .

SCIENCE, 1990, 248 (4959) :1109-1112

[9]

KING NW, 1990, J MED PRIMATOL, V19, P109

[10] ANALYSIS OF SIMIAN IMMUNODEFICIENCY VIRUS SEQUENCE VARIATION IN TISSUES OF RHESUS MACAQUES WITH SIMIAN AIDS [J].

KODAMA, T ;

MORI, K ;

KAWAHARA, T ;

RINGLER, DJ ;

DESROSIERS, RC .

JOURNAL OF VIROLOGY, 1993, 67 (11) :6522-6534