INVOLVEMENT OF HEME COMPONENTS IN STEROL-METABOLISM OF SACCHAROMYCES-CEREVISIAE

被引：56

作者：

LORENZ, RT ^{[1
]}

PARKS, LW ^{[1
]}

机构：

[1] N CAROLINA STATE UNIV,DEPT MICROBIOL,RALEIGH,NC 27695

来源：

LIPIDS | 1991年 / 26卷 / 08期

关键词：

D O I：

10.1007/BF02536423

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is an intimate association between sterol biosynthesis in yeast and aerobicity. Besides the requirement for molecular oxygen for the epoxidation of squalene, cytochrome hemoproteins are involved in demethylation and desaturation steps. Regulatory effects of hemes on sterol formation have been demonstrated using specifically defective mutants of yeast. Heme competency participates in a mechanism whereby wild-type cells are prevented from taking exogenous sterols from the growth media. The multiple interactions of hemes and sterols appear to be associated with the variously defined functions for sterols in the yeast cells.

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页码：598 / 603

页数：6

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