SYNTHESIS OF LIPOPHILIC PHOSPHATE TRIESTER DERIVATIVES OF 5-FLUOROURIDINE AND ARABINOCYTIDINE AS ANTICANCER PRODRUGS

被引：17

作者：

LEBEC, C

HUYNHDINH, T

机构：

[1] Unité de Chimie Organique, URA 487 CNRS, Département de Biochimie et de Génétique Moléculaire, 75724 Paris Cedex 15

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 45期

关键词：

D O I：

10.1016/0040-4039(91)80219-V

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The phosphoramidite method was applied for the preparation of phosphotriesters of anticancer nucleosides. By this way, derivatives of 5-fluorouridine (5-FU) and arabinofuranosylcytidine (ara-C) were synthesized as possible membrane anchored prodrugs.

引用

页码：6553 / 6556

页数：4

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