SYNTHESIS OF (2S,4S) 2-CARBOXY-4-PYRROLIDINE ACETIC-ACID, A CONFORMATIONALLY CONSTRAINED 2-AMINO ADIPIC ACID ANALOG

被引：43

作者：

LANGLOIS, N

ROJAS, A

机构：

[1] Institut de Chimie des Substances Naturelles, C.N.R.S.

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 15期

关键词：

PYROGLUTAMIC ACID; EXCITATORY AMINO-ACIDS; ALKYL BROMOACETATE; SODIUM CYANOBOROHYDRIDE;

D O I：

10.1016/S0040-4039(00)60445-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(2S,4S) 2-carboxy-4-pyrrolidine acetic acid was synthesized from (S) pyroglutamic acid in 26% overall yield by a regiospecific deprotonation of the N-methoxycarbonyl benzylester 4.

引用

页码：2477 / 2480

页数：4

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