PHARMACEUTICAL APPLICATIONS OF A BONDED CYCLODEXTRIN STATIONARY-PHASE

Open tubular columns were coated with Chirasil-Dex, a polysiloxane anchored permethylated beta-cyclodextrin stationary phase. A number of chiral separations of pharmaceuticals and agrichemicals are presented to demonstrate the usefulness of this stationary phase in both GC and SFC. Racemates of various amines, amino acids, amino alcohols, carboxylic acids, coumarines, diols, and imides were resolved. To achieve acceptable separation of some enantiomers, a series of derivatives were studied. In many cases, cyclic derivatives and free acids gave the highest enantioselectivity.