PHARMACEUTICAL APPLICATIONS OF A BONDED CYCLODEXTRIN STATIONARY-PHASE

被引:19
作者
JUVANCZ, Z
GROLIMUND, K
SCHURIG, V
机构
[1] CIBA GEIGY AG,DEPT CENT ANALYT,CH-4002 BASEL,SWITZERLAND
[2] UNIV TUBINGEN,INST ORGAN CHEM,W-7400 TUBINGEN 1,GERMANY
关键词
CAPILLARY GAS CHROMATOGRAPHY; SUPERCRITICAL FLUID CHROMATOGRAPHY; ENANTIOMER SEPARATION; CHIRASIL-DEX; PHARMACEUTICAL APPLICATIONS; OPTIMIZATION;
D O I
10.1002/mcs.1220050510
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Open tubular columns were coated with Chirasil-Dex, a polysiloxane anchored permethylated beta-cyclodextrin stationary phase. A number of chiral separations of pharmaceuticals and agrichemicals are presented to demonstrate the usefulness of this stationary phase in both GC and SFC. Racemates of various amines, amino acids, amino alcohols, carboxylic acids, coumarines, diols, and imides were resolved. To achieve acceptable separation of some enantiomers, a series of derivatives were studied. In many cases, cyclic derivatives and free acids gave the highest enantioselectivity.
引用
收藏
页码:459 / 468
页数:10
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