HPLC DETERMINATION OF TOCOPHEROL, RETINOL, DEHYDRORETINOL AND RETINYL PALMITATE IN TISSUES OF LAKE CHAR (SALVELINUS-NAMAYCUSH) EXPOSED TO COPLANAR 3,3',4,4',5-PENTACHLOROBIPHENYL

被引：55

作者：

PALACE, VP ^{[1
]}

BROWN, SB ^{[1
]}

机构：

[1] FISHERIES & OCEANS CANADA, WINNIPEG R3T 2N6, MANITOBA, CANADA

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 1994年 / 13卷 / 03期

关键词：

VITAMIN-E; VITAMIN-A; RETINOIDS; COPLANAR PCB;

D O I：

10.1002/etc.5620130315

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Tocopherol, retinol, dehydroretinol, and retinyl palmitate were measured by reversed-phase HPLC in liver, kidney, and plasma of lake char exposed to orally administered coplanar 3,3,4,4,5-pentachlorobiphenyl (PCB). Tocopherol concentrations were unaffected after eight weeks. Liver retinol, dehydroretinol, and retinyl palmitate concentrations were lower, whereas kidney retinyl palmitate was elevated in PCB-exposed groups. Tissue retinoid concentrations provide sensitive indicators of coplanar PCB exposure in fish.

引用

页码：473 / 476

页数：4

共 28 条

[1] SIMULTANEOUS DETERMINATION OF RETINOL, ALPHA-TOCOPHEROL AND BETA-CAROTENE IN SERUM BY ISOCRATIC HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

ARNAUD, J ;

FORTIS, I ;

BLACHIER, S ;

KIA, D ;

FAVIER, A .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1991, 572 (1-2) :103-116

[2] BINDING OF A METABOLITE OF 3,4,3',4'-TETRACHLOROBIPHENYL TO TRANSTHYRETIN REDUCES SERUM VITAMIN-A TRANSPORT BY INHIBITING THE FORMATION OF THE PROTEIN COMPLEX CARRYING BOTH RETINOL AND THYROXINE [J].

BROUWER, A ;

VANDENBERG, KJ .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1986, 85 (03) :301-312

[3]

BURTON GW, 1990, ANNU REV NUTR, V10, P357, DOI 10.1146/annurev.nutr.10.1.357

[4] POLYCHLORINATED AND POLYBROMINATED BIPHENYL CONGENERS AND RETINOID LEVELS IN RAT-TISSUES - STRUCTURE-ACTIVITY-RELATIONSHIPS [J].

CHEN, LC ;

BERBERIAN, I ;

KOCH, B ;

MERCIER, M ;

AZAISBRAESCO, V ;

GLAUERT, HP ;

CHOW, CK ;

ROBERTSON, LW .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1992, 114 (01) :47-55

[5] THE VITAMIN-E REQUIREMENT OF RAINBOW-TROUT (SALMO-GAIRDNERI) GIVEN DIETS CONTAINING POLY-UNSATURATED FATTY-ACIDS DERIVED FROM FISH OIL [J].

COWEY, CB ;

ADRON, JW ;

YOUNGSON, A .

AQUACULTURE, 1983, 30 (1-4) :85-93

[6] SERUM CONCENTRATIONS OF RETINOL, D-ALPHA-TOCOPHEROL AND BETA-CAROTENE - EFFECTS OF STORAGE AT - 70-DEGREES-C FOR 5 YEARS [J].

EDMONDS, BK ;

NIERENBERG, DW .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1993, 614 (01) :169-174

[7]

FOX GA, 1993, IN PRESS J GREAT LAK

[8] BIOCONVERSION PATHWAY OF ASTAXANTHIN INTO RETINOL-2 IN MATURE RAINBOW-TROUT (SALMO-GAIRDNERI RICH) [J].

GUILLOU, A ;

CHOUBERT, G ;

STOREBAKKEN, T ;

DELANOUE, J ;

KAUSHIK, S .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1989, 94 (03) :481-485

[9]

HAKANSSON H, 1991, J NUTR SCI VITAMINOL, V37, P239, DOI 10.3177/jnsv.37.239

[10] THE VITAMINS REQUIRED FOR CULTIVATED SALMONIDS [J].

HALVER, JE .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1982, 73 (01) :43-50

← 1 2 3 →