HETEROGENEOUS DISTRIBUTION AND DEVELOPMENTAL-CHANGE OF METABOTROPIC GLUTAMATE RECEPTORS IN RAT HIPPOCAMPAL CA1 PYRAMIDAL NEURONS

被引：7

作者：

SHIRASAKI, T ^{[1
]}

MUNAKATA, M ^{[1
]}

AKAIKE, N ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT NEUROPHYSIOL,1-1 SEIRYO CHO,AOBA KU,SENDAI,MIYAGI 980,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 157卷 / 02期

关键词：

HIPPOCAMPAL CA1 NEURON; PERFORATED-PATCH TECHNIQUE; METABOTROPIC GLU RECEPTOR; K+ CURRENT; REGIONAL DISTRIBUTION; DEVELOPMENTAL CHANGE;

D O I：

10.1016/0304-3940(93)90734-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The metabotropic glutamate (mGlu) response in dissociated rat hippocampal CA1 pyramidal neurons was recorded, using the nystatin-perforated patch-clamp technique. The mGlu response was localized in the ventral site of the hippocampal CA1 region, In both the ventral and dorsal sites of the CA1 region, the current amplitude of the mGlu responses as well as their induction probability (responsiveness) were reduced with development of the brain.

引用

页码：191 / 194

页数：4

共 20 条

[1]

ABE T, 1992, J BIOL CHEM, V267, P13361

[2] HETEROGENEOUS DISTRIBUTION OF TETRODOTOXIN-SENSITIVE CALCIUM-CONDUCTING CHANNELS IN RAT HIPPOCAMPAL CA1 NEURONS [J].

AKAIKE, N ;

TAKAHASHI, K ;

MORIMOTO, M .

BRAIN RESEARCH, 1991, 556 (01) :135-138

[3] SIGNAL TRANSDUCTION AND PHARMACOLOGICAL CHARACTERISTICS OF A METABOTROPIC GLUTAMATE RECEPTOR, MGLUR1, IN TRANSFECTED CHO CELLS [J].

ARAMORI, I ;

NAKANISHI, S .

NEURON, 1992, 8 (04) :757-765

[4]

BEHNISH T, 1991, TRENDS PHARMACOL SCI, V12, P357

[5]

CONDORELLI DF, 1992, MOL PHARMACOL, V41, P660

[6] VINTAGE AMINO-ACID MEETING DESCRIBES NEW TOOLS FOR AMINO-ACID RESEARCH, SUBTYPES OF METABOTROPIC RECEPTORS [J].

HENLEY, JM ;

JOHNSTON, GAR .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (10) :357-359

[7] MUSCARINIC ACTIVATION OF IONIC CURRENTS MEASURED BY A NEW WHOLE-CELL RECORDING METHOD [J].

HORN, R ;

MARTY, A .

JOURNAL OF GENERAL PHYSIOLOGY, 1988, 92 (02) :145-159

[8] 2-AMINO-3-PHOSPHONOPROPIONATE BLOCKS THE INDUCTION AND MAINTENANCE OF LONG-TERM POTENTIATION IN RAT HIPPOCAMPAL SLICES [J].

IZUMI, Y ;

CLIFFORD, DB ;

ZORUMSKI, CF .

NEUROSCIENCE LETTERS, 1991, 122 (02) :187-190

[9] SEQUENCE AND EXPRESSION OF A METABOTROPIC GLUTAMATE RECEPTOR [J].

MASU, M ;

TANABE, Y ;

TSUCHIDA, K ;

SHIGEMOTO, R ;

NAKANISHI, S .

NATURE, 1991, 349 (6312) :760-765

[10] THE EFFECTS OF TRANS-ACPD ON LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE [J].

MCGUINNESS, N ;

ANWYL, R ;

ROWAN, M .

NEUROREPORT, 1991, 2 (11) :688-690

← 1 2 →