LOCALIZATION OF THE HUMAN BETA-CATENIN GENE (CTNNB1) TO 3P21 - A REGION IMPLICATED IN TUMOR-DEVELOPMENT

被引：110

作者：

KRAUS, C

LIEHR, T

HULSKEN, J

BEHRENS, J

BIRCHMEIER, W

GRZESCHIK, KH

BALLHAUSEN, WG

机构：

[1] UNIV ERLANGEN NURNBERG,INST HUMANGENET,D-91054 ERLANGEN,GERMANY

[2] MAX DELBRUCK CENTRUM MOLEK MED,D-13122 BERLIN,GERMANY

[3] UNIV MARBURG,ZENTRUM MED HUMANGENET,D-35033 MARBURG,GERMANY

来源：

GENOMICS | 1994年 / 23卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1493

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The human beta-catenin locus (CTNNB1) was mapped by in situ fluorescence analysis to band p21 on the short arm of chromosome 3, a region frequently affected by somatic alterations in a variety of tumors. PCR primers for the genomic amplification of beta-catenin sequences were selected on the basis of homology to exon 4 of the Drosophila armadillo gene. Analysis of a panel of somatic cell hybrids confirmed the localization of beta-catenin on human chromosome 3. Furthermore, exclusion mapping of three hybrids carrying defined fragments of the short arm of human chromosome 3 allowed us to determine the position of the CTNNB1 locus close to the marker D3S2 in 3p21. (C) 1994 Academic Press, Inc.

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页码：272 / 274

页数：3

相关论文

共 22 条

[1] DETECTION OF THE PHILADELPHIA-CHROMOSOME IN INTERPHASE NUCLEI [J].

ARNOLDUS, EPJ ;

WIEGANT, J ;

NOORDERMEER, IA ;

WESSELS, JW ;

BEVERSTOCK, GC ;

GROSVELD, GC ;

VANDERPLOEG, M ;

RAAP, AK .

CYTOGENETICS AND CELL GENETICS, 1990, 54 (3-4) :108-&

[2] DISSECTING TUMOR-CELL INVASION - EPITHELIAL-CELLS ACQUIRE INVASIVE PROPERTIES AFTER THE LOSS OF UVOMORULIN-MEDIATED CELL CELL-ADHESION [J].

BEHRENS, J ;

MAREEL, MM ;

VANROY, FM ;

BIRCHMEIER, W .

JOURNAL OF CELL BIOLOGY, 1989, 108 (06) :2435-2447

[3] LOSS OF EPITHELIAL DIFFERENTIATION AND GAIN OF INVASIVENESS CORRELATES WITH TYROSINE PHOSPHORYLATION OF THE E-CADHERIN BETA-CATENIN COMPLEX IN CELLS TRANSFORMED WITH A TEMPERATURE-SENSITIVE V-SRC GENE [J].

BEHRENS, J ;

VAKAET, L ;

FRIIS, R ;

WINTERHAGER, E ;

VANROY, F ;

MAREEL, MM ;

BIRCHMEIER, W .

JOURNAL OF CELL BIOLOGY, 1993, 120 (03) :757-766

[4] REGIONAL LOCALIZATION OF A TROPHOBLAST ANTIGEN-RELATED SEQUENCE AND 16 OTHER SEQUENCES TO HUMAN CHROMOSOME-6Q USING SOMATIC-CELL HYBRIDS [J].

BOYLE, JM ;

HEY, Y ;

MYERS, K ;

STERN, PL ;

GRZESCHIK, FH ;

IKEHARA, Y ;

MISUMI, Y ;

FOX, M .

GENOMICS, 1992, 12 (04) :693-698

[5] MUTATION IN THE DNA MISMATCH REPAIR GENE HOMOLOG HMLH1 IS ASSOCIATED WITH HEREDITARY NONPOLYPOSIS COLON-CANCER [J].

BRONNER, CE ;

BAKER, SM ;

MORRISON, PT ;

WARREN, G ;

SMITH, LG ;

LESCOE, MK ;

KANE, M ;

EARABINO, C ;

LIPFORD, J ;

LINDBLOM, A ;

TANNERGARD, P ;

BOLLAG, RJ ;

GODWIN, AR ;

WARD, DC ;

NORDENSKJOLD, M ;

FISHEL, R ;

KOLODNER, R ;

LISKAY, RM .

NATURE, 1994, 368 (6468) :258-261

[6] PLAKOGLOBIN AND BETA-CATENIN - DISTINCT BUT CLOSELY RELATED [J].

BUTZ, S ;

STAPPERT, J ;

WEISSIG, H ;

KEMLER, R .

SCIENCE, 1992, 257 (5073) :1142-1144

[7] ASSIGNMENT OF THE GENE CODING FOR HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN TO MOUSE CHROMOSOME-9 [J].

DEGEN, SJF ;

GILBERT, DJ ;

JENKINS, NA ;

COPELAND, NG .

GENOMICS, 1992, 13 (04) :1368-1369

[8] MODES OF DAPI BANDING AND SIMULTANEOUS INSITU HYBRIDIZATION [J].

HENG, HHQ ;

TSUI, LC .

CHROMOSOMA, 1993, 102 (05) :325-332

[9] FROM CADHERINS TO CATENINS - CYTOPLASMIC PROTEIN INTERACTIONS AND REGULATION OF CELL-ADHESION [J].

KEMLER, R .

TRENDS IN GENETICS, 1993, 9 (09) :317-321

[10] DEFINITION OF A TUMOR SUPPRESSOR LOCUS WITHIN HUMAN CHROMOSOME-3P21-P22 [J].

KILLARY, AM ;

WOLF, ME ;

GIAMBERNARDI, TA ;

NAYLOR, SL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :10877-10881