INSULIN SIGNAL-TRANSDUCTION PATHWAYS

被引：47

作者：

QUON, MJ

BUTTE, AJ

TAYLOR, SI

机构：

[1] Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 09期

关键词：

D O I：

10.1016/1043-2760(94)90104-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin initiates its pleiotropic effects by activating the insulin receptor tyrosine kinase to phosphorylate several intracellular proteins. Recent studies have demonstrated that phosphotyrosine residues bind specifically to proteins that contain src homology 2 (SH2) domains, and that this interaction mediates the regulation of multiple intracellular signaling pathways. This article reviews recent progress in elucidating the detailed pathways that lead from the insulin receptor to the ultimate biologic actions of insulin.

引用

页码：369 / 376

页数：8

共 66 条

[1] Ahn Natalie G., 1992, Current Opinion in Cell Biology, V4, P992, DOI 10.1016/0955-0674(92)90131-U
[2] AMINO-ACID POLYMORPHISMS OF INSULIN-RECEPTOR SUBSTRATE-1 IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS
ALMIND, K
BJORBAEK, C
VESTERGAARD, H
HANSEN, T
ECHWALD, S
PEDERSEN, O
[J]. LANCET, 1993, 342 (8875) : 828 - 832
[3] BINDING OF THE RAS ACTIVATOR SON OF SEVENLESS TO INSULIN-RECEPTOR SUBSTRATE-1 SIGNALING COMPLEXES
BALTENSPERGER, K
KOZMA, LM
CHERNIACK, AD
KLARLUND, JK
CHAWLA, A
BANERJEE, U
CZECH, MP
[J]. SCIENCE, 1993, 260 (5116) : 1950 - 1952
[4] SH3 DOMAINS DIRECT CELLULAR-LOCALIZATION OF SIGNALING MOLECULES
BARSAGI, D
ROTIN, D
BATZER, A
MANDIYAN, V
SCHLESSINGER, J
[J]. CELL, 1993, 74 (01) : 83 - 91
[5] THE SOS (SON OF SEVENLESS) PROTEIN
BARSAGI, D
[J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1994, 5 (04) : 165 - 169
[6] BERGHE NVD, 1994, MOL CELL BIOL, V14, P2372
[7] SIGNAL-TRANSDUCTION VIA THE MAP KINASES - PROCEED AT YOUR OWN RSK
BLENIS, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) : 5889 - 5892
[8] EPIDERMAL GROWTH-FACTOR REGULATES P21(RAS) THROUGH THE FORMATION OF A COMPLEX OF RECEPTOR, GRB2 ADAPTER PROTEIN, AND SOS NUCLEOTIDE EXCHANGE FACTOR
BUDAY, L
DOWNWARD, J
[J]. CELL, 1993, 73 (03) : 611 - 620
[9] INSULIN STIMULATION OF GENE-EXPRESSION MEDIATED BY P21RAS ACTIVATION
BURGERING, BMT
MEDEMA, RH
MAASSEN, JA
VANDEWETERING, ML
VANDEREB, AJ
MCCORMICK, F
BOS, JL
[J]. EMBO JOURNAL, 1991, 10 (05) : 1103 - 1109
[10] POSSIBLE INVOLVEMENT OF NORMAL P21 H-RAS IN THE INSULIN INSULINLIKE GROWTH FACTOR-I SIGNAL TRANSDUCTION PATHWAY
BURGERING, BMT
SNIJDERS, AJ
MAASSEN, JA
VANDEREB, AJ
BOS, JL
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (10) : 4312 - 4322

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