LOCALIZATION OF NITRIC-OXIDE SYNTHASE IMMUNOREACTIVITY IN MAST-CELLS OF HUMAN NASAL-MUCOSA

被引：28

作者：

BACCI, S

ARBIRICCARDI, R

MAYER, B

RUMIO, C

BORGHICIRRI, MB

机构：

[1] UNIV FLORENCE,DEPT HUMAN ANAT & HISTOL,SECT E ALLARA,I-50139 FLORENCE,ITALY

[2] GRAZ UNIV,INST PHARMACOL & TOXICOL,GRAZ,AUSTRIA

[3] KARL ZEISS,MILAN,ITALY

来源：

HISTOCHEMISTRY | 1994年 / 102卷 / 02期

关键词：

D O I：

10.1007/BF00269011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nitric oxide (NO)-synthase immunoreactivity has been detected for the first time in mast cells of human normal nasal mucosa, with an antibody specific for neuronal NO-synthase, Intense immunoreactivity was revealed in secretion granules of mast cells but was found in mast cell granules free in the extracellular matrix only in some instances; no reactivity was found in the cytoplasm of this or other cell types. These findings suggest that human nasal mast cells contain a particulate isoform of NO-synthase, which shares epitopes with neuronal NO-synthase and is rapidly removed from granules upon exocytosis.

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页码：89 / 92

页数：4

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