CHANGES IN THE SEROTONERGIC SYSTEM DURING THE SLEEP-WAKE CYCLE - SIMULTANEOUS POLYGRAPHIC AND VOLTAMMETRIC RECORDINGS IN HYPOTHALAMUS USING A TELEMETRY SYSTEM

被引：52

作者：

IMERI, L

DESIMONI, MG

GIGLIO, R

CLAVENNA, A

MANCIA, M

机构：

[1] IST FISIOL UMANA 2,I-20133 MILAN,ITALY

[2] IST RIC FARMACOL MARIO NEGRI,I-20157 MILAN,ITALY

来源：

NEUROSCIENCE | 1994年 / 58卷 / 02期

关键词：

D O I：

10.1016/0306-4522(94)90042-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Changes in the serotonergic system in the posterior hypothalamus of freely moving rats were related to sleep and wakefulness using in viva voltammetry (with carbon fiber microelectrodes) and polygraphic recordings. By using an optoelectronic telemetry system for the voltammetric signals, electrical cross-talk between the two settings was avoided and simultaneous neurochemical and electrophysiological recordings could be made so that a detailed time course of events could be obtained. Extracellular levels of the serotonin metabolite, 5-hydroxyindolacetic acid, measured every 2 min, increased with wakefulness and decreased with sleep: levels were significantly lower during desynchronized sleep than slow wave sleep. In vivo voltammetry associated with the optoelectronic telemetry system appears to be a useful tool for studying the relationship between neurochemical changes and electrophysiological events.

引用

页码：353 / 358

页数：6

共 43 条

[31] CENTRAL METABOLISM OF SEROTONIN IN CAT DURING INSOMINIA - NEUROPHYSIOLOGICAL AND BIOCHEMICAL STUDY AFTER ADMINISTRATION OF P-CHLOROPHENYLALANINE OR DESTRUCTION OF RAPHE SYSTEM [J].