ANTIPHOSPHOLIPID ANTIBODIES AND PREGNANCY LOSS

被引：29

作者：

OUT, HJ

BRUINSE, HW

DERKSEN, RHWM

机构：

[1] Department of Internal Medicine, Division of Immunopathology

[2] Department of Obstetrics and Gynaecology, University Hospital Utrecht, 3508 GA Utrecht

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 06期

关键词：

ABORTION; ANTICARDIOLIPIN ANTIBODIES; ANTIPHOSPHOLIPID ANTIBODY; LUPUS ANTICOAGULANT; PREGNANCY;

D O I：

10.1093/oxfordjournals.humrep.a137446

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Anti-phospholipid antibodies such as the lupus anticoagulant and anti-cardiolipin antibodies, are antibodies directed at negatively charged phospholipids and have received much attention in the last decade. Their presence has been associated with a thrombotic tendency, leading to a variety of clinical symptoms. In the pregnant woman, the presence of these antibodies may have consequences for management, since retrospective reports have established a correlation between the lupus anticoagulant or anti-cardiolipin antibodies with intrauterine fetal death, probably due to placental thrombosis. This article reviews current knowledge on anti-phospholipid antibodies in relation to pregnancy loss, focusing on clinical aspects.

引用

页码：889 / 897

页数：9

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