ANTIPHOSPHOLIPID ANTIBODIES AND PREGNANCY LOSS

被引：29

作者：

OUT, HJ

BRUINSE, HW

DERKSEN, RHWM

机构：

[1] Department of Internal Medicine, Division of Immunopathology

[2] Department of Obstetrics and Gynaecology, University Hospital Utrecht, 3508 GA Utrecht

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 06期

关键词：

ABORTION; ANTICARDIOLIPIN ANTIBODIES; ANTIPHOSPHOLIPID ANTIBODY; LUPUS ANTICOAGULANT; PREGNANCY;

D O I：

10.1093/oxfordjournals.humrep.a137446

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Anti-phospholipid antibodies such as the lupus anticoagulant and anti-cardiolipin antibodies, are antibodies directed at negatively charged phospholipids and have received much attention in the last decade. Their presence has been associated with a thrombotic tendency, leading to a variety of clinical symptoms. In the pregnant woman, the presence of these antibodies may have consequences for management, since retrospective reports have established a correlation between the lupus anticoagulant or anti-cardiolipin antibodies with intrauterine fetal death, probably due to placental thrombosis. This article reviews current knowledge on anti-phospholipid antibodies in relation to pregnancy loss, focusing on clinical aspects.

引用

页码：889 / 897

页数：9

共 107 条

[71]

Maier D.B., Parke A., Subclinical autoimmunity in recurrent aborters, Fenil. Steril, 51, pp. 280-285, (1989)

[72]

Mangat G.K., Hom S., Sturgess A., Anticardiolipin antibodies in a normal pregnant population (Abstract), Clin. Exp. Rheumatol, 8, (1990)

[73]

Nilsson I.M., Astedt B., Hcdner U., Berezin D., Intrauterine death and circulating anticoagulant (‘antithromboplastin’), Acta Med. Scand, 197, pp. 153-159, (1975)

[74]

Ordi J., Barquinero J., Vilardell M., Jordan R., Tolosa C., Selva A., Genover E., Fetal loss treatment in patients with antiphospholipid antibodies, Ann. Rheum. Dis, 48, pp. 798-802, (1989)

[75]

Out Groot De H.J.P.G., Hasselaar P., Vliet Van M., Derksen R.H.W.M., Fluctuations of anticardiolipin antibody levels in patients with systemic lupus erythematosus: A prospective study, Ann. Rheum, 48, pp. 1023-1028, (1989)

[76]

Out H.J., Bruinse H.W., Christiaens G.C.M.L., Meilof J.F., Vliet Van M., Groot De P.G., Smeenk R.J.T., Derksen R.H.W.M., (, Ann. Rheum. Dis., in Press, (1991)

[77]

Parazzini F., Acaia B., Ricciardiello O., Fedele L., Liati P., Candiani G.B., Short-term reproductive prognosis when no cause can be found for recurrent miscarriage, Br.J. Obstet. Gynaecol, 95, pp. 654-658, (1988)

[78]

Parke A., Maier D., Hakim Randolph C.J., Andreoli J., Subclinical autoimmune disease and recurrent spontaneous abortion, J. Rheumatol, 13, pp. 1178-1180, (1986)

[79]

Parke A., Maier D., Wilson D., Reoli J., Ballow M., Intravenous gamma-globulin, anti-phospholipid antibodies, and pregnancy, Ann. Intern. Med, 110, pp. 495-496, (1989)

[80]

Petri M., Rheinschmidt M., Whiting-O'keefe Q., Heilman D., Corash L., The frequency of lupus anticoagulant in systemic lupus erythematosus. [A study of sixty consecutive patients with APTT, RVVT, and ACA level. ], Ann. Intern. Med, 106, pp. 524-531, (1987)

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