THE LARGE-SCALE IMMOBILIZATION OF PENICILLIUM-CHRYSOGENUM - BATCH AND CONTINUOUS OPERATION IN AN AIRLIFT REACTOR

被引：27

作者：

KESHAVARZ, T

EGLIN, R

WALKER, E

BUCKE, C

HOLT, G

BULL, AT

LILLY, MD

机构：

[1] UNIV KENT,BIOL LAB,CANTERBURY CT2 7NJ,KENT,ENGLAND

[2] UNIV LONDON UNIV COLL,DEPT CHEM & BIOCHEM ENGN,CTR BIOCHEM ENGN,SERC,LONDON WC1E 7JE,ENGLAND

[3] POLYTECH CENT LONDON,SCH BIOTECHNOL,LONDON W1M 8JS,ENGLAND

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 1990年 / 36卷 / 08期

关键词：

D O I：

10.1002/bit.260360802

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A temperature‐sensitive cell division cycle mutant of Penicillium chrysogenum P2 has been immobilized on Celite and grown in a 250–320‐L working volume air‐lift fermenter. The ability to uncouple growth and penicillin synthesis by raising the temperature to 30 °C also overcame the problem of the free cell mass which appeared after 300 h operation with the parent organism. After 500 h operation, penicillin and ACV dimer were still being synthesized. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：763 / 770

页数：8

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