CHOLECYSTOKININ ANTIANALGESIA - SAFETY CUES ABOLISH MORPHINE ANALGESIA

被引：128

作者：

WIERTELAK, EP

MAIER, SF

WATKINS, LR

机构：

来源：

SCIENCE | 1992年 / 256卷 / 5058期

关键词：

D O I：

10.1126/science.1589765

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Environmental stimuli that signal the occurrence of aversive or dangerous events activate endogenous opiate analgesia systems. Signals for safety (the nonoccurrence of aversive events) produce the opposite and inhibit environmentally produced analgesia. Stimuli that signal safety are now shown to abolish the analgesic effect of morphine, even when morphine is applied directly to spinal cord. Further, this antiopiate effect occurs because the environmental stimulus leads to release of the neuropeptide cholecystokinin in the spinal cord. This process may contribute to the regulation of pain and the development of opiate tolerance.

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页码：830 / 833

页数：4

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