KETAMINE DECREASES PLASMA-CATECHOLAMINES AND IMPROVES OUTCOME FROM INCOMPLETE CEREBRAL-ISCHEMIA IN RATS

被引:103
作者
HOFFMAN, WE
PELLIGRINO, D
WERNER, C
KOCHS, E
ALBRECHT, RF
ESCH, JS
机构
[1] UNIV ILLINOIS, DEPT ANESTHESIOL, CHICAGO, IL 60680 USA
[2] UNIV HOSP EPPENDORF, DEPT ANESTHESIOL, HAMBURG, GERMANY
关键词
ANESTHETICS; INTRAVENOUS; FENTANYL; KETAMINE; BRAIN; BLOOD FLOW; ISCHEMIA; RECEPTORS; EXCITATORY; N-METHYL-D-ASPARTATE; SYMPATHETIC NERVOUS SYSTEM; CATECHOLAMINES; EPINEPHRINE; NOREPINEPHRINE;
D O I
10.1097/00000542-199205000-00014
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Central neuroexcitatory receptors (N-methyl-D-aspartate [NMDA], non-NMDA) may affect outcome from cerebral ischemia by altering sympathetic nervous system activity. We tested whether ketamine, an NMDA antagonist, and NBQX, a non-NMDA antagonist, improve outcome from incomplete cerebral ischemia in the rat and whether a change in outcome is related to changes in plasma catecholamines. There were five treatment groups: group 1 (control, n = 10) received a fentanyl infusion at a rate of 25-mu-g.kg-1.h-1 and ventilation with 70% N2O in O2. Group 2 (n = 10) received the same anesthetic treatment and were given an intraperitoneal injection of 30 mg/kg NBQX 15 min prior to ischemia. Group 3 (n = 10) received a ketamine infusion of 1.0 mg.kg-1.min-1 and ventilation with room air. Group 4 (n = 10) received a ketamine infusion of 1.5 mg.kg-1.min-1. Group 5 received a ketamine infusion of 1 mg.kg-1.min-1 plus a 6 ml/kg intraperitoneal injection of 40% glucose solution 15 min before the start of ischemia. Ischemia was produced by right common carotid ligation combined with hemorrhagic hypotension to 35 mmHg for 30 min. Blood gases, pH, and skull temperature were controlled during ischemia. Plasma glucose increased during ischemia in all groups but was lower in ketamine-anesthetized rats (groups 3 and 4). Glucose-loaded ketamine-anesthetized rats (group 5) had plasma glucose concentrations similar to the control group. Plasma epinephrine and norepinephrine concentrations were significantly less in ketamine-anesthetized rats (groups 3, 4, and 5) during ischemia compared to controls (P < 0.05). Neurologic outcome was significantly better (P < 0.05) in all ketamine-treated rats (groups 3, 4, and 5) compared to the control group, regardless of plasma glucose concentration during ischemia. NBQX did not improve neurologic outcome. These results suggest that ketamine improves neurologic outcome from incomplete cerebral ischemia by a mechanism related to a decrease in plasma catecholamine activity.
引用
收藏
页码:755 / 762
页数:8
相关论文
共 35 条
  • [21] KETAMINE-INDUCED CHANGES IN REGIONAL GLUCOSE-UTILIZATION IN THE RAT-BRAIN
    NELSON, SR
    HOWARD, RB
    CROSS, RS
    SAMSON, F
    [J]. ANESTHESIOLOGY, 1980, 52 (04) : 330 - 334
  • [22] PROTECTIVE EFFECT OF THE GLUTAMATE ANTAGONIST, MK-801 IN FOCAL CEREBRAL-ISCHEMIA IN THE CAT
    OZYURT, E
    GRAHAM, DI
    WOODRUFF, GN
    MCCULLOCH, J
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (01) : 138 - 143
  • [23] THE GLUTAMATE ANTAGONIST MK-801 REDUCES FOCAL ISCHEMIC BRAIN-DAMAGE IN THE RAT
    PARK, CK
    NEHLS, DG
    GRAHAM, DI
    TEASDALE, GM
    MCCULLOCH, J
    [J]. ANNALS OF NEUROLOGY, 1988, 24 (04) : 543 - 551
  • [24] PFEIFER G, 1981, ANASTH INTENSIVTHER, V3, P125
  • [25] PRADO R, 1988, J CEREB BLOOD FLOW M, V8, P6
  • [26] MODERATE HYPERGLYCEMIA AUGMENTS ISCHEMIC BRAIN-DAMAGE - A NEUROPATHOLOGIC STUDY IN THE RAT
    PULSINELLI, WA
    WALDMAN, S
    RAWLINSON, D
    PLUM, F
    [J]. NEUROLOGY, 1982, 32 (11) : 1239 - 1246
  • [27] RANSOM BR, 1990, STROKE, V21, P52
  • [28] EXCITOTOXICITY AND THE NMDA RECEPTOR
    ROTHMAN, SM
    OLNEY, JW
    [J]. TRENDS IN NEUROSCIENCES, 1987, 10 (07) : 299 - 302
  • [29] 2,3-DIHYDROXY-6-NITRO-7-SULFAMOYL-BENZO(F)QUINOXALINE - A NEUROPROTECTANT FOR CEREBRAL-ISCHEMIA
    SHEARDOWN, MJ
    NIELSEN, EO
    HANSEN, AJ
    JACOBSEN, P
    HONORE, T
    [J]. SCIENCE, 1990, 247 (4942) : 571 - 574
  • [30] COMPARISON OF THE EFFECTS OF MK-801 AND PHENCYCLIDINE ON CATECHOLAMINE UPTAKE AND NMDA-INDUCED NOREPINEPHRINE RELEASE
    SNELL, LD
    YI, SJ
    JOHNSON, KM
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 145 (02) : 223 - 226