HOMOLOGATION OF L-PHENYLALANINE TO KETOMETHYLENE AND HYDROXYETHYLENE DIPEPTIDE ISOSTERES VIA 2-THIAZOLYL AMINO KETONE INTERMEDIATE

被引：27

作者：

DONDONI, A

PERRONE, D

机构：

[1] Dipartimento di Chimica, Laboratorio di Chimica Organica, Università, Ferrara

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 47期

关键词：

THIAZOLE; L-PHENYLALANINE; HOMOLOGATION; DIPEPTIDE ISOSTERS;

D O I：

10.1016/S0040-4039(00)60888-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient route is presented for the synthesis of N-protected isosteric dipeptides Phepsi[COCH2]Gly and Phepsi[CH(OH)CH2]Phe from L-phenylalanine through 2-thiazolyl alpha-amino ketone and delta-amino-gamma-hydroxy-(E)-alpha,beta-enoate derivatives as key intermediates.

引用

页码：7259 / 7262

页数：4

共 36 条

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