DE-NOVO PROTEIN DESIGN - FROM MOLTEN GLOBULES TO NATIVE-LIKE STATES

被引：188

作者：

BETZ, SF

RALEIGH, DP

DEGRADO, WF

机构：

[1] SF Betz, DP Raleigh and WF DeGrado, The Dupont Merck Pharmaceutical Co

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/0959-440X(93)90090-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances in the field of de novo protein design are examined. The data are examined with respect to the hypothesis that most designed proteins exhibit characteristics similar to those of molten globules. Continuing efforts to produce novel proteins with the specific interactions that define natural proteins are assessed, and the impact that these efforts have had on our understanding of protein structure, stability, and folding is discussed.

引用

页码：601 / 610

页数：10

共 79 条

[71] HELICHROME - SYNTHESIS AND ENZYMATIC-ACTIVITY OF A DESIGNED HEMEPROTEIN [J].