FLUOROOLEFIN PEPTIDE ISOSTERES - TOOLS FOR CONTROLLING PEPTIDE CONFORMATIONS

被引：77

作者：

BOROS, LG

DECORTE, B

GIMI, RH

WELCH, JT

WU, Y

HANDSCHUMACHER, RE

机构：

[1] SUNY ALBANY,DEPT CHEM,ALBANY,NY 12222

[2] YALE UNIV,SCH MED,DEPT PHARMACOL,NEW HAVEN,CT 06510

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 33期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0040-4039(94)88067-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluoroolefin dipeptide isosteres were synthesized applying the Peterson reaction as a novel for fluoroolefination. The dipeptide isosteres were elaborated to provide the conformationally constrained analogs (1-(R), 1-(S) and 2-(R), 2-(S)) of the Suc-Ala-Gly-Pro-Phe-pNA tetrapeptide, a synthetic substrate of cyclophilin.

引用

页码：6033 / 6036

页数：4

共 20 条

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