BEHAVIORAL-EFFECTS OF THE MU-OPIOID PEPTIDE AGONISTS DAMGO, DALDA, AND PL017 ON LOCOMOTOR ACTIVITIES

被引：18

作者：

MEYER, ME

机构：

[1] Department of Psychology, University of Florida, Gainesville

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 46卷 / 02期

关键词：

MU-OPIOID PEPTIDE AGONISTS; DAMGO; DALDA; PL017; LOCOMOTOR ACTIVITY;

D O I：

10.1016/0091-3057(93)90369-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The relative role of central mu-opioid receptor agonists Tyr-D-Ala-Gly-N-Methyl-Phe-Gly-ol (DAMGO), Tyr-D-Arg-Phe-Lys (DALDA), and Tyr-Pro-MePhe-D-Pro (PL017) (0.00, 0.01, 0.1, or 1.0 mu g, ICV) on behavior was investigated in rats for 60 min in activity monitors. DAMGO (0.1 and 1.0 mu g) and PL017 (1.0 mu g) resulted in biphasic effects, inhibition followed by hyperactivity for linear locomotor, whereas the 0.01-mu g dosage was associated with hyperactivity. On the other hand, DALDA (0.1 and 1.0 mu g) suppressed locomotor activity over the 60-min session.

引用

页码：391 / 395

页数：5

共 28 条

[1] EFFECTS OF METHIONINE-ENKEPHALIN AND MORPHINE ON SPONTANEOUS LOCOMOTOR-ACTIVITY - ANTAGONISM BY NALOXONE [J].

BHARGAVA, HN .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1978, 9 (02) :167-171

[2]

BRADY LS, 1981, J PHARMACOL EXP THER, V218, P613

[3] CHRONIC MORPHINE-INDUCED HYPERACTIVITY IN RATS IS ALTERED BY NUCLEUS ACCUMBENS AND VENTRAL TEGMENTAL LESIONS [J].

BUNNEY, WC ;

MASSARI, VJ ;

PERT, A .

PSYCHOPHARMACOLOGY, 1984, 82 (04) :318-321

[4]

CORBETT AD, 1993, HDB EXPT PHARM, P645

[5] INDUCTION OF CATALEPSY AND HYPERACTIVITY BY MORPHINE ADMINISTERED DIRECTLY INTO NUCLEUS ACCUMBENS OF RATS [J].

COSTALL, B ;

FORTUNE, DH ;

NAYLOR, RJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 49 (01) :49-64

[6] COMPARISON OF THE BEHAVIORAL-EFFECTS INDUCED BY ADMINISTRATION IN RAT NUCLEUS ACCUMBENS OR NUCLEUS CAUDATUS OF SELECTIVE MU AND DELTA OPIOID-PEPTIDES OR KELATORPHAN AN INHIBITOR OF ENKEPHALIN-DEGRADING-ENZYMES [J].

DAUGE, V ;

ROSSIGNOL, P ;

ROQUES, BP .

PSYCHOPHARMACOLOGY, 1988, 96 (03) :343-352

[7] MULTIPLE OPIOID RECEPTORS - CRITERIA FOR IDENTIFICATION AND CLASSIFICATION [J].

GOLDSTEIN, A ;

JAMES, IF .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1984, 5 (12) :503-505

[8] ANALOGS OF BETA-LPH61-64 POSSESSING SELECTIVE AGONIST ACTIVITY AT MU-OPIATE RECEPTORS [J].

HANDA, BK ;

LANE, AC ;

LORD, JAH ;

MORGAN, BA ;

RANCE, MJ ;

SMITH, CFC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1981, 70 (04) :531-540

[9] LOCOMOTOR-ACTIVITY OF RATS AFTER INJECTION OF VARIOUS OPIOIDS INTO THE NUCLEUS ACCUMBENS AND THE SEPTUM MEDIALE [J].

HAVEMANN, U ;

KUSCHINSKY, K .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1985, 331 (2-3) :175-180

[10] BEHAVIORAL-EFFECTS OF LOW AND HIGH ACUTE DOSES OF MORPHINE IN SOLITARY MICE [J].

HECHT, A ;

SCHIORRING, E .

PSYCHOPHARMACOLOGY, 1979, 64 (01) :73-79

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