ROLE OF THE RAB3A GTPASE IN REGULATED SECRETION FROM NEUROENDOCRINE CELLS

被引：12

作者：

MACARA, IG

机构：

[1] The Department of Pathology, University of Vermont Medical College, Burlington

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/1043-2760(94)P3201-H

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Regulated secretion is a complex process that involves scores of distinct proteins, These proteins must assemble into machines that organize vesicle docking, membrane fusion, and recovery of vesicle components. Rab3A, a member of the Ras superfamily of GTPases, associates with secretory granule membranes of neuroendocrine cells, and mutants of Rab3A can inhibit exocytosis. A model is proposed in which Rab3A controls the assembly and disassembly of a docking complex that inhibits membrane fusion until an external signal triggers release of the Rab3A from the complex.

引用

收藏

页码：267 / 271

页数：5

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