RING SIZE EFFECT IN THE PKC INHIBITORY ACTIVITIES OF PERHYDROAZEPINE ANALOGS OF BALANOL

被引：28

作者：

LAI, YS

MENALDINO, DS

NICHOLS, JB

JAGDMANN, GE

MYLOTT, F

GILLESPIE, J

HALL, SE

机构：

[1] Sphinx Pharmaceuticals A Division of Eli Lilly and Company, Durham, NC 27707

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 18期

关键词：

D O I：

10.1016/0960-894X(95)00365-Z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogs 3-5 of balanol (-)-1, a potent protein kinase C (PKC) inhibitor, were synthesized with the perhydroazepine moiety replaced by a smaller ring. Their in vitro inhibitory activities against PKC revealed a significant relationship between ring size and potency.

引用

页码：2151 / 2154

页数：4

共 16 条

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