SYNTHESIS AND IN-VITRO CYTOTOXICITY OF 6-VINYLURIDINE AND RELATED-COMPOUNDS

被引：12

作者：

MEGATI, S

SODUM, R

OTTER, GM

KLEIN, RS

OTTER, BA

机构：

[1] ALBERT EINSTEIN COLL MED,CTR CANC,BRONX,NY 10467

[2] MONTEFIORE MED CTR,DEPT ONCOL,MED CHEM LAB,BRONX,NY 10467

[3] MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/0960-894X(94)80018-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 6-alkenyluracil nucleosides (7a-e) and bases (14a-i) were synthesized and evaluated for their ability to inhibit the growth of mouse leukemia L1210 cells in vitro. While several of the free bases are cytotoxic, with IC50 values in the 1 - 5 mu M range, the corresponding beta-D-ribofuranosyl nucleosides are not significantly active.

引用

页码：469 / 472

页数：4

共 12 条

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