EFFECT OF HYDROXYL GROUP CONFIGURATION IN HYDROXYETHYLAMINE DIPEPTIDE ISOSTERES ON HIV PROTEASE INHIBITION - EVIDENCE FOR MULTIPLE BINDING MODES

被引：133

作者：

RICH, DH

SUN, CQ

PRASAD, JVNV

PATHIASSERIL, A

TOTH, MV

MARSHALL, GR

CLARE, M

MUELLER, RA

HOUSEMAN, K

机构：

[1] UNIV WISCONSIN,DEPT CHEM,MADISON,WI 53706

[2] WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110

[3] GD SEARLE & CO,RES & DEV,DEPT MOLEC & CELL BIOL,SKOKIE,IL 60077

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 03期

关键词：

D O I：

10.1021/jm00107a049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：1222 / 1225

页数：4

共 27 条

[1]

ARROWSMITH RJ, 1988, PEPT P EUR S, P393

[2]

BILLICH S, 1988, J BIOL CHEM, V263, P17905

[3] ON THE RATIONAL DESIGN OF RENIN INHIBITORS - X-RAY STUDIES OF ASPARTIC PROTEINASES COMPLEXED WITH TRANSITION-STATE ANALOGS [J].

BLUNDELL, TL ;

COOPER, J ;

FOUNDLING, SI ;

JONES, DM ;

ATRASH, B ;

SZELKE, M .

BIOCHEMISTRY, 1987, 26 (18) :5585-5590

[4] 3-DIMENSIONAL STRUCTURE OF THE COMPLEX OF THE RHIZOPUS-CHINENSIS CARBOXYL PROTEINASE AND PEPSTATIN AT 2.5-A RESOLUTION [J].

BOTT, R ;

SUBRAMANIAN, E ;

DAVIES, DR .

BIOCHEMISTRY, 1982, 21 (26) :6956-6962

[5] INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE INVITRO - RATIONAL DESIGN OF SUBSTRATE-ANALOG INHIBITORS [J].

DREYER, GB ;

METCALF, BW ;

TOMASZEK, TA ;

CARR, TJ ;

CHANDLER, AC ;

HYLAND, L ;

FAKHOURY, SA ;

MAGAARD, VW ;

MOORE, ML ;

STRICKLER, JE ;

DEBOUCK, C ;

MEEK, TD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :9752-9756

[6] DESIGN, ACTIVITY, AND 2.8 A CRYSTAL-STRUCTURE OF A C2 SYMMETRICAL INHIBITOR COMPLEXED TO HIV-1 PROTEASE [J].

ERICKSON, J ;

NEIDHART, DJ ;

VANDRIE, J ;

KEMPF, DJ ;

WANG, XC ;

NORBECK, DW ;

PLATTNER, JJ ;

RITTENHOUSE, JW ;

TURON, M ;

WIDEBURG, N ;

KOHLBRENNER, WE ;

SIMMER, R ;

HELFRICH, R ;

PAUL, DA ;

KNIGGE, M .

SCIENCE, 1990, 249 (4968) :527-533

[7] A STEREOCONTROLLED SYNTHESIS OF HYDROXYETHYLENE DIPEPTIDE ISOSTERES USING NOVEL, CHIRAL AMINOALKYL EPOXIDES AND GAMMA-(AMINOALKYL) GAMMA-LACTONES [J].

EVANS, BE ;

RITTLE, KE ;

HOMNICK, CF ;

SPRINGER, JP ;

HIRSHFIELD, J ;

VEBER, DF .

JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (23) :4615-4625

[8]

FITZGERALD PMD, 1990, J BIOL CHEM, V265, P14209

[9] DESIGN OF PEPTIDE DERIVED AMINO-ALCOHOLS AS TRANSITION-STATE ANALOG INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME [J].

GORDON, EM ;

GODFREY, JD ;

PLUSCEC, J ;

VONLANGEN, D ;

NATARAJAN, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 126 (01) :419-426

[10]

HANDA BK, 1989, Patent No. 346847

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