INTERLEUKIN-1-BETA DISSOCIATES BETA-AMYLOID PRECURSOR PROTEIN AND BETA-AMYLOID PEPTIDE SECRETION

被引：28

作者：

VASILAKOS, JP ^{[1
]}

CARROLL, RT ^{[1
]}

EMMERLING, MR ^{[1
]}

DOYLE, PD ^{[1
]}

DAVIS, RE ^{[1
]}

KIM, KS ^{[1
]}

SHIVERS, BD ^{[1
]}

机构：

[1] NEW YORK STATE INST BASIC RES DEV DISABIL, STATEN ISL, NY 10314 USA

来源：

FEBS LETTERS | 1994年 / 354卷 / 03期

关键词：

BETA-AMYLOID PRECURSOR PROTEIN; BETA-AMYLOID PEPTIDE; INTERLEUKIN; 1-BETA; H4; NEUROGLIOMA;

D O I：

10.1016/0014-5793(94)01142-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A heightened production of interleukin 1 beta (IL-1 beta) has been reported in microglial-associated amyloid deposits in Alzheimer's disease (AD) brains. These plaques are composed predominantly of beta/A4 peptide derived from beta-amyloid precursor protein (beta APP). We demonstrate that short-term (1 h) IL-1 beta-treatment increases beta APP(s) secretion and concomitantly decreases cell-associated beta APP in human H4 neuroglioma cells. Long-term (5 h) IL-1 beta treatment did not alter secreted or cell-associated beta APP content. In contrast, the secretion of beta/A4-containing epitope was not affected by short-term IL-1 beta stimulation; however, long-term IL-1 beta treatment decreased the amount of beta/A4-containing epitope secreted from the cells. These results show that IL-1 beta modifies the processing and secretion of beta APP to exacerbate perhaps the neuropathology of AD.

引用

页码：289 / 292

页数：4

共 22 条

[1] EXACT CLEAVAGE SITE OF ALZHEIMER AMYLOID PRECURSOR IN NEURONAL PC-12 CELLS
ANDERSON, JP
ESCH, FS
KEIM, PS
SAMBAMURTI, K
LIEBERBURG, I
ROBAKIS, NK
[J]. NEUROSCIENCE LETTERS, 1991, 128 (01) : 126 - 128
[2] CALCIUM REGULATES PROCESSING OF THE ALZHEIMER AMYLOID PROTEIN-PRECURSOR IN A PROTEIN-KINASE C-INDEPENDENT MANNER
BUXBAUM, JD
RUEFLI, AA
PARKER, CA
CYPESS, AM
GREENGARD, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (10) : 4489 - 4493
[3] PROTEIN-PHOSPHORYLATION INHIBITS PRODUCTION OF ALZHEIMER AMYLOID-BETA/A4 PEPTIDE
BUXBAUM, JD
KOO, EH
GREENGARD, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) : 9195 - 9198
[4] CHOLINERGIC AGONISTS AND INTERLEUKIN-1 REGULATE PROCESSING AND SECRETION OF THE ALZHEIMER BETA/A4 AMYLOID PROTEIN-PRECURSOR
BUXBAUM, JD
OISHI, M
CHEN, HI
PINKASKRAMARSKI, R
JAFFE, EA
GANDY, SE
GREENGARD, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10075 - 10078
[5] PHOSPHOLIPASE-A(2) ACTIVATION INFLUENCES THE PROCESSING AND SECRETION OF THE AMYLOID PRECURSOR PROTEIN
EMMERLING, MR
MOORE, CJ
DOYLE, PD
CARROLL, RT
DAVIS, RE
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 197 (01) : 292 - 297
[6] EXPRESSION OF AMYLOID PRECURSOR PROTEIN MESSENGER-RNAS IN ENDOTHELIAL, NEURONAL AND GLIAL-CELLS - MODULATION BY INTERLEUKIN-1
FORLONI, G
DEMICHELI, F
GIORGI, S
BENDOTTI, C
ANGERETTI, N
[J]. MOLECULAR BRAIN RESEARCH, 1992, 16 (1-2): : 128 - 134
[7] INHIBITION OF BETA-AMYLOID PRODUCTION BY ACTIVATION OF PROTEIN-KINASE-C
GABUZDA, D
BUSCIGLIO, J
YANKNER, BA
[J]. JOURNAL OF NEUROCHEMISTRY, 1993, 61 (06) : 2326 - 2329
[8] REGULATION OF BETA-AMYLOID PRECURSOR PROTEIN ISOFORM MESSENGER-RNAS BY TRANSFORMING GROWTH-FACTOR-BETA-1 AND INTERLEUKIN-1-BETA IN ASTROCYTES
GRAY, CW
PATEL, AJ
[J]. MOLECULAR BRAIN RESEARCH, 1993, 19 (03): : 251 - 256
[9] GRIFFIN WST, 1989, P NATL ACAD SCI USA, V86, P7611
[10] HUNG AY, 1993, J BIOL CHEM, V268, P22959

← 1 2 3 →