SCHIZOSACCHAROMYCES-POMBE STE11+ ENCODES A TRANSCRIPTION FACTOR WITH AN HMG MOTIF THAT IS A CRITICAL REGULATOR OF SEXUAL DEVELOPMENT

被引：299

作者：

SUGIMOTO, A ^{[1
]}

IINO, Y ^{[1
]}

MAEDA, T ^{[1
]}

WATANABE, Y ^{[1
]}

YAMAMOTO, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC SCI,DEPT BIOPHYS & BIOCHEM,TOKYO 113,JAPAN

来源：

GENES & DEVELOPMENT | 1991年 / 5卷 / 11期

关键词：

SCHIZOSACCHAROMYCES-POMBE; NITROGEN STARVATION; SEXUAL DIFFERENTIATION; TRANSCRIPTION FACTOR; HIGH-MOBILITY GROUP PROTEIN BOX; DNA-BINDING ACTIVITY;

D O I：

10.1101/gad.5.11.1990

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Schizosaccharomyces pombe ste11 encodes a member of the family of HMG-box proteins. Its transcript is induced in response to nitrogen starvation and a concomitant decrease of the intracellular cAMP level. Expression of ste11 is essential for induction of sexual development, and its ectopic expression stimulates uncontrolled mating and sporulation. Ste11 protein regulates positively transcription of the following genes required for sexual development: the mating type genes, matP and matM, and the mei2 gene, which is essential for commitment to meiosis. Ste11 protein synthesized in vitro binds specifically to a DNA fragment carrying a 10-base motif TTCTTTGTTY that is an essential cis-acting element for the induction of mei2 and is commonly seen in the upstream regions of the genes inducible by nitrogen starvation. These observations strongly suggest that Ste11 serves as a key transcription factor for sexual development.

引用

页码：1990 / 1999

页数：10

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