RECEPTOR EXPRESSION IN OLFACTORY NEURONS DURING RAT DEVELOPMENT - IN-SITU HYBRIDIZATION STUDIES

被引：59

作者：

STROTMANN, J ^{[1
]}

WANNER, I ^{[1
]}

HELFRICH, T ^{[1
]}

BREER, H ^{[1
]}

机构：

[1] UNIV STUTTGART HOHENHEIM,INST ZOOPHYSIOL,D-70599 STUTTGART,GERMANY

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1995年 / 7卷 / 03期

关键词：

ODORANT RECEPTORS; EXPRESSION PATTERNS; DEVELOPMENT; IN SITU HYBRIDIZATION; RAT;

D O I：

10.1111/j.1460-9568.1995.tb00345.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In situ hybridization approaches have been employed to explore the onset and time course of odorant receptor expression during the prenatal development of rats. The critical phase for the maturation of the olfactory system from embryonic day (E) 12 to E18 was analysed. The onset of expression of four receptor genes (OR5, OR14, OR37 and OR124) was found between day E12 and E14. In the early phase of development (E14) a distinct receptor subtype was expressed only in a few hundred neurons; the number increased about two- to three-fold within a 2 day interval. From the very beginning, spatial segregation of receptor subtypes in distinct expression zones was observed.

引用

页码：492 / 500

页数：9

共 24 条

[11] VERTEBRATE OLFACTORY RECEPTION
LANCET, D
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 : 329 - 355
[12] EXPRESSION OF OLFACTORY RECEPTOR AND TRANSDUCTION GENES DURING RAT DEVELOPMENT
MARGALIT, T
LANCET, D
[J]. DEVELOPMENTAL BRAIN RESEARCH, 1993, 73 (01): : 7 - 16
[13] MENCO BPM, 1985, J CELL SCI, V78, P283
[14] SPATIAL PATTERN OF RECEPTOR EXPRESSION IN THE OLFACTORY EPITHELIUM
NEF, P
HERMANSBORGMEYER, I
ARTIERESPIN, H
BEASLEY, L
DIONNE, VE
HEINEMANN, SF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) : 8948 - 8952
[15] CODING OF OLFACTORY INFORMATION - TOPOGRAPHY OF ODORANT RECEPTOR EXPRESSION IN THE CATFISH OLFACTORY EPITHELIUM
NGAI, J
CHESS, A
DOWLING, MM
NECLES, N
MACAGNO, ER
AXEL, R
[J]. CELL, 1993, 72 (05) : 667 - 680
[16] LIPOSOMES AS A MODEL FOR OLFACTORY CELLS - CHANGES IN MEMBRANE-POTENTIAL IN RESPONSE TO VARIOUS ODORANTS
NOMURA, T
KURIHARA, K
[J]. BIOCHEMISTRY, 1987, 26 (19) : 6135 - 6140
[17] PARMENTIER M, 1991, NATURE, V355, P453
[18] CLONING AND EXPRESSION OF ODORANT RECEPTORS
RAMING, K
KRIEGER, J
STROTMANN, J
BOEKHOFF, I
KUBICK, S
BAUMSTARK, C
BREER, H
[J]. NATURE, 1993, 361 (6410) : 353 - 356
[19] A ZONAL ORGANIZATION OF ODORANT RECEPTOR GENE-EXPRESSION IN THE OLFACTORY EPITHELIUM
RESSLER, KJ
SULLIVAN, SL
BUCK, LB
[J]. CELL, 1993, 73 (03) : 597 - 609
[20] RECEPTOR CELL RESPONSES TO ODORANTS - SIMILARITIES AND DIFFERENCES AMONG ODORANTS
SICARD, G
HOLLEY, A
[J]. BRAIN RESEARCH, 1984, 292 (02) : 283 - 296

← 1 2 3 →