IMPROVED METHODS FOR 3'-O-SUCCINYLATION OF 2'-DEOXYRIBONUCLEOSIDES AND RIBONUCLEOSIDES AND THEIR COVALENT ANCHORING ON POLYMER SUPPORTS FOR OLIGONUCLEOTIDE SYNTHESIS

被引：23

作者：

KUMAR, P ^{[1
]}

GHOSH, NN ^{[1
]}

SADANA, KL ^{[1
]}

GARG, BS ^{[1
]}

GUPTA, KC ^{[1
]}

机构：

[1] UNIV DELHI,CTR BIOCHEM TECHNOL,NUCLEIC ACIDS RES LAB,MALL RD,DELHI 110007,INDIA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1993年 / 12卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1080/07328319308019012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A more convenient and efficient method is described for the preparation of 3'-O-succinates of 2'-deoxyribo- and ribonucleosides, in a variety of solvents. Also, a new one-pot procedure has been developed for anchoring these succinates to polymer supports, suitable for solid phase synthesis of oligonucleotides.

引用

页码：565 / 584

页数：20

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