1,3-IMINOKETONES AS NEW SYNTHONS FOR THE STEREOCONTROLLED PREPARATION OF USEFUL CARBAPENEM INTERMEDIATES

被引：3

作者：

ALCAIDE, B

PEREZCASTELLS, J

SANCHEZVIGO, B

SIERRA, MA

机构：

[1] Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期

关键词：

1,3-IMINOKETONES; BETA-LACTAMS; CARBAPENEMS; ANTIBIOTICS; STAUDINGER REACTION;

D O I：

10.1016/S0960-894X(01)80957-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient, totally stereoselective two-step synthesis of cis- and trans-carbapenem intermediates based upon the reaction of N-methoxycarbonylmethyl 1,3-iminoketones 1 with benzyloxyacetyl chloride followed by a stereocontrolled intramolecular aldol-type condensation, has been developed.

引用

页码：2369 / 2374

页数：6

共 40 条

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