SYNTHETIC STUDIES ON QUINOCARCIN AND ITS RELATED-COMPOUNDS .3. SYNTHESIS OF 5-SUBSTITUTED AND 3,5-DISUBSTITUTED-2-FORMYL-PYRROLIDINE DERIVATIVES, THE KEY D-RING FRAGMENTS OF ENANTIOMERIC PAIRS OF QUINOCARCIN AND 10-DECARBOXYQUINOCARCIN

被引：57

作者：

KATOH, T ^{[1
]}

NAGATA, Y ^{[1
]}

KOBAYASHI, Y ^{[1
]}

ARAI, K ^{[1
]}

MINAMI, J ^{[1
]}

TERASHIMA, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON | 1994年 / 50卷 / 21期

关键词：

QUINOCARCIN; 10-DECARBOXYQUINOCARCIN; D-RING FRAGMENT; 5-SUBSTITUTED-2-FORMYLPYRROLDINE; 3,5-DISUBSTITUTED-2-FORMYLPYRROLIDINE; GLUTAMIC ACID; PYROGLUTAMIC ACID;

D O I：

10.1016/S0040-4020(01)80643-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title synthesis was accomplished by employing each enantiomer of glutamic acid and pyroglutamic acid as chiral starting materials and featuring formation of an N-protected aminal, substitution of the methoxy group with a cyanide anion, and reduction of the cyanide function to an aldehyde as common key steps.

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页码：6221 / 6238

页数：18

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