TOTAL SYNTHESIS OF BALANOL - A POTENT PROTEIN-KINASE-C INHIBITOR OF FUNGAL ORIGIN

被引：54

作者：

ADAMS, CP

FAIRWAY, SM

HARDY, CJ

HIBBS, DE

HURSTHOUSE, MB

MORLEY, AD

SHARP, BW

VICKER, N

WARNER, I

机构：

[1] RHONE POULENC RORER,DAGENHAM RES CTR,DAGENHAM RM10 7XS,ESSEX,ENGLAND

[2] UNIV WALES COLL CARDIFF,SCH CHEM & APPL CHEM,CARDIFF CF1 3TB,S GLAM,WALES

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 18期

关键词：

D O I：

10.1039/p19950002355

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the fungal metabolite balanol, a potent inhibitor of protein kinase C, is described. The synthesis includes a novel synthesis of 3-amino-4-hydroxyazepanes via a directed ring expansion of 3-bromopiperidin-4-ones.

引用

页码：2355 / 2362

页数：8

共 23 条

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