LINKAGE TO XQ28 IN A FAMILY WITH NONSPECIFIC X-LINKED MENTAL-RETARDATION

被引：30

作者：

NORDSTROM, AM

PENTTINEN, M

VONKOSKULL, H

机构：

[1] UNIV HELSINKI,CENT HOSP,DEPT GYNECOL,SF-00290 HELSINKI 29,FINLAND

[2] UNIV TURKU,CENT HOSP,DEPT CLIN GENET,SF-20520 TURKU 52,FINLAND

来源：

HUMAN GENETICS | 1992年 / 90卷 / 03期

关键词：

D O I：

10.1007/BF00220075

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Linkage analysis was performed in a family with nonspecific X-linked mental retardation (MRX). Affected individuals had no clinical characteristics other than mental retardation. Linkage was detected to the marker loci DXS477, DXS465, DXS52, DXS15 and F8C with maximum lod scores of 1.70, 1.32, 2.52, 1.70, and 1.09, respectively (theta = 0.0). The results strongly indicate that the gene for mental retardation in the family studied maps close to DXS52.

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页码：263 / 266

页数：4

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