AUTOCRINE OR PARACRINE INFLAMMATORY ACTIONS OF CORTICOTROPIN-RELEASING HORMONE INVIVO

被引：432

作者：

KARALIS, K

SANO, H

REDWINE, J

LISTWAK, S

WILDER, RL

CHROUSOS, GP

机构：

[1] NIAMSD,ARTHRIT & RHEUMATISM BRANCH,BETHESDA,MD 20892

[2] NIMH,ALCOHOL DRUG ABUSE & MENTAL HLTH ADM,CLIN NEUROENDOCRINOL BRANCH,BETHESDA,MD 20892

[3] NICHHD,DEV ENDOCRINOL BRANCH,BETHESDA,MD 20892

来源：

SCIENCE | 1991年 / 254卷 / 5030期

关键词：

D O I：

10.1126/science.1925600

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Corticotropin-releasing hormone (CRH) functions as a regulator of the hypothalamic-pituitary-adrenal axis and coordinator of the stress response. CRH receptors exist in peripheral sites of the immune system, and CRH promotes several immune functions in vitro. The effect of systemic immunoneutralization of CRH was tested in an experimental model of chemically induced aseptic inflammation in rats. Intraperitoneal administration of rabbit antiserum to CRH caused suppression of both inflammatory exudate volume and cell concentration by approximately 50 to 60 percent. CRH was detected in the inflamed area but not in the systemic circulation. Immunoreactive CRH is therefore produced in peripheral inflammatory sites where, in contrast to its systemic indirect immunosuppressive effects, it acts as an autocrine or paracrine inflammatory cytokine.

引用

页码：421 / 423

页数：3

共 57 条

[11] PHYSIOLOGICAL AND BEHAVIORAL-RESPONSES TO CORTICOTROPIN-RELEASING FACTOR ADMINISTRATION - IS CRF A MEDIATOR OF ANXIETY OR STRESS RESPONSES [J].