POPULATION GENETIC-STUDY OF THE HUMAN DOPAMINE TRANSPORTER GENE (DAT1)

被引:69
作者
DOUCETTESTAMM, LA
BLAKELY, DJ
TIAN, J
MOCKUS, S
MAO, J
机构
[1] Collaborative Research, A Division of Genome Therapeutics Corporation, Waltham, Massachusetts
关键词
ALLELE; GENOTYPE; ETHNIC GROUPS;
D O I
10.1002/gepi.1370120307
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The human dopamine transporter gene, DAT1, acts to transport released dopamine into presynaptic terminals of the brain. The possibility that the DAT1 gene plays a role in genetic diseases of the brain has led to studies of DAT1 in several psychiatric and neurological disorders. Previous sequence analysis of DAT1 revealed a 40-bp repeat in the 3' end of the gene. In order to identify all potential alleles for this VNTR marker a population database was established. One thousand seventy-four unrelated individuals were screened by PCR for the region containing the 40 bp repeat. Allele frequency differences were found between black Americans and Caucasians or Hispanics but no differences were observed between Caucasians and Hispanics. A previously unreported allele was detected in all three populations. Thus, we have shown that screening a large population identifies new alleles and generates more accurate allele frequencies. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:303 / 308
页数:6
相关论文
共 8 条
[1]   HUMAN DOPAMINE TRANSPORTER GENE NOT LINKED TO SCHIZOPHRENIA IN MULTIGENERATIONAL PEDIGREES [J].
BYERLEY, W ;
COON, H ;
HOFF, M ;
HOLIK, J ;
WALDO, M ;
FREEDMAN, R ;
CARON, MG ;
GIROS, B .
HUMAN HEREDITY, 1993, 43 (05) :319-322
[2]  
GIROS B, 1992, MOL PHARMACOL, V42, P383
[3]   GENETIC-DIFFERENCES AT 4 DNA TYPING LOCI IN FINNISH, ITALIAN, AND MIXED CAUCASIAN POPULATIONS [J].
KRANE, DE ;
ALLEN, RW ;
SAWYER, SA ;
PETROV, DA ;
HARTL, DL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :10583-10587
[4]   DOPAMINE TRANSPORTER GENE POLYMORPHISMS ARE NOT ASSOCIATED WITH POLYSUBSTANCE ABUSE [J].
PERSICO, AM ;
VANDENBERGH, DJ ;
SMITH, SS ;
UHL, GR .
BIOLOGICAL PSYCHIATRY, 1993, 34 (04) :265-267
[5]   ABNORMAL DOPAMINE UPTAKE SITES IN POSTMORTEM STRIATUM FROM PATIENTS WITH TOURETTE SYNDROME [J].
SINGER, HS ;
HAHN, IH ;
MORAN, TH .
ANNALS OF NEUROLOGY, 1991, 30 (04) :558-562
[6]   ANALYSIS OF 6 VNTR LOCI BY MULTIPLEX PCR AND AUTOMATED FLUORESCENT DETECTION [J].
TULLY, G ;
SULLIVAN, KM ;
GILL, P .
HUMAN GENETICS, 1993, 92 (06) :554-562
[7]  
UHL GR, 1993, ADV NEUROL, V60, P321
[8]   HUMAN DOPAMINE TRANSPORTER GENE (DAT1) MAPS TO CHROMOSOME-5P15.3 AND DISPLAYS A VNTR [J].
VANDENBERGH, DJ ;
PERSICO, AM ;
HAWKINS, AL ;
GRIFFIN, CA ;
LI, X ;
JABS, EW ;
UHL, GR .
GENOMICS, 1992, 14 (04) :1104-1106