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JUMPING TRANSLOCATION OF 9Q IN A CASE OF FOLLICULAR LYMPHOMA

被引：15
作者：
WLODARSKA, I
MECUCCI, C
DEWOLFPEETERS, C
VERHOEF, G
WEIER, HU
CASSIMAN, JJ
VANDENBERGHE, H
机构：
[1] CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,DEPT PATHOL,B-3000 LOUVAIN,BELGIUM
[2] CATHOLIC UNIV LEUVEN,DEPT HEMATOL,B-3000 LOUVAIN,BELGIUM
[3] UNIV PERUGIA,INST HEMATOL,I-06100 PERUGIA,ITALY
[4] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,DIV MOLEC CYTOMETRY,SAN FRANCISCO,CA 94143
来源：
CANCER GENETICS AND CYTOGENETICS | 1994年 / 76卷 / 02期
关键词：
D O I：
10.1016/0165-4608(94)90465-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytogenetic and fluorescence in situ hybridization (FISH) studies on a t(l4;18)-positive follicular lymphoma presenting a remarkable pattern of secondary chromosomal changes are reported. Chromosome analysis of a lymph node biopsy performed at diagnosis revealed the presence of four related subclones characterized by the (14;18) translocation alone or together with one of the following anomalies: add(1)(p36), add(13)(q34), or der(12)(12;13) (q24;q24)add(13)(q34). The chromosome 9 origin of the extra material on the abnormal chromosomes 1 and 13 was demonstrated by FISH and points to a ''jumping'' translocation in the present case.
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收藏
页码：140 / 144
页数：5
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