CONVENIENT PREPARATION OF ALPHA-TRIMETHYLSILYLOXY-HYDROXYSTANNANE AND ALPHA-HYDROXYSTANNANE FROM ALDEHYDES

被引：12

作者：

BHATT, RK

YE, JH

FALCK, JR

机构：

[1] UNIV TEXAS,SOUTHWESTERN MED CTR,DEPT MOLEC GENET,DALLAS,TX 75235

[2] UNIV TEXAS,SOUTHWESTERN MED CTR,DEPT PHARMACOL,DALLAS,TX 75235

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 24期

关键词：

STANNYLHYDRIN; TIN; CHIRAL INDUCTION; TRIMETHYL(TRIBUTYLSTANNYL)SILANE;

D O I：

10.1016/S0040-4039(00)73117-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldehydes, but not ketones, are converted to alpha-hydroxystannanes via the corresponding silyl ethers in good to excellent yields by Bu(4)NCN catalyzed addition of Bu(3)SnSiMe(3) and hydrolytic isolation. Modest asymmetric induction was observed using a chiral quaternary ammonium cyanide catalyst.

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页码：4081 / 4084

页数：4

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