BASIC ACTIONS OF TRANSFORMING GROWTH-FACTOR-ALPHA AND RELATED PEPTIDES

被引：14

作者：

COFFEY, RJ

GANGAROSA, LM

DAMSTRUP, L

DEMPSEY, PJ

机构：

[1] Departments of Medicine and Cell Biology, Vanderbilt University, Nashville, TN

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1995年 / 7卷 / 10期

关键词：

TRANSFORMING GROWTH FACTOR-ALPHA; AEPIDERMAL GROWTH FACTOR; AMPHIREGULIN; HEPARIN-BINDING ECF-LIKE GROWTH FACTOR;

D O I：

10.1097/00042737-199510000-00003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Transforming growth factor-alpha (TGF-alpha) and related peptides have been implicated in a wide range of biological activities, including cell growth, differentiation and acid inhibition. This chapter reviews the roles of TGF-alpha in the stomach, the insights gained into the action of the TGF-alpha a Family of growth factors from the study of polarized epithelial cells and the confirmation of events mediated by the epidermal growth factor receptor (EGFR) by the study of mice in which the EGFR has been disrupted by homologous recombination.

引用

页码：923 / 927

页数：5

共 49 条

[41]

Fowler K.J., Walker F., Alexander W., Hibbs M.L., Nice E.C., Bohmer R.M., Et al., A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation, Proc Natl Acad Sci USA, 92, pp. 1465-1469, (1995)

[42]

Threadgill D.W., Dlugosz A.A., Hansen L., Tennenbaum T., U L., Yee D., Et al., Targeted disruption of mouse EGF-receptor: Evidence that genetic background affects mutant phenotype, Science, 269, pp. 230-234, (1995)

[43]

Sibilia M., Wagner E.F., Strain-dependent epithelial defects in mice lacking the EGF receptor, Science, 269, pp. 234-238, (1995)

[44]

Miettinen P.J., Berger J.E., Meneses J., Phung Y., Pedersen R.A., Werb Z, et al:. Epithelial immaturity and multiorgan failure in mice deficient in the epidermal growth factor receptor, Nature, 376, pp. 337-341, (1995)

[45]

Das S.K., Tsukamura H., Paria B.C., Rews G.K., Dey S.K., Differential expression of epidermal growth factor receptor (EGF-R) bioactivity by progesterone and estrogen in the adult mouse uterus, Endocrinology, 134, pp. 971-981, (1994)

[46]

Paria B.C., Das S.K., Rews G.K., Dey S.K., Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation, Proc Natl Acad Sci USA, 90, pp. 55-59, (1993)

[47]

Das S.K., Wang X.-N., Paria B.C., Damm D., Abraham J.A., Klagsbrun M., Et al., Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: A possible ligand for interaction with blastocyst EGF-receptor in implantation, Development, 120, pp. 1071-1083, (1994)

[48]

Wang X.-N., Das S.K., Damm D., Klagsbrun M., Abraham J.A., Dey S.K., Differential regulation of heparin-binding epidermal growth factor-like growth factor in the adult ovariec-tomized mouse uterus by progesterone and estrogen, Endocrinology, 135, pp. 1264-1271, (1994)

[49]

Das S.K., Chakraborty I., Paria B.C., Wang X.-N., Plowman G., Dey S.K., Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus, Mol Endocrinol, 9, pp. 691-705, (1995)

← 1 2 3 4 5 →