Mechanism of alternative splicing and its regulation

被引：308

作者：

Wang, Yan ^{[1
]}

Liu, Jing ^{[1
]}

Huang, Bo ^{[1
]}

Xu, Yan-Mei ^{[1
]}

Li, Jing ^{[2
]}

Huang, Lin-Feng ^{[1
]}

Lin, Jin ^{[1
]}

Zhang, Jing ^{[1
]}

Min, Qing-Hua ^{[1
]}

Yang, Wei-Ming ^{[1
]}

Wang, Xiao-Zhong ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Dept Clin Lab Med, 1 Min De Rd, Nanchang 330006, Peoples R China

[2] Nanchang Univ, Affiliated Hosp 1, Dept Clin Lab Med, Nanchang 330006, Peoples R China

来源：

BIOMEDICAL REPORTS | 2015年 / 3卷 / 02期

基金：

美国国家科学基金会;

关键词：

alternative splicing; regulation; precursor mRNA; mechanism; disease;

D O I：

10.3892/br.2014.407

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Alternative splicing of precursor mRNA is an essential mechanism to increase the complexity of gene expression, and it plays an important role in cellular differentiation and organism development. Regulation of alternative splicing is a complicated process in which numerous interacting components are at work, including cis-acting elements and trans-acting factors, and is further guided by the functional coupling between transcription and splicing. Additional molecular features, such as chromatin structure, RNA structure and alternative transcription initiation or alternative transcription termination, collaborate with these basic components to generate the protein diversity due to alternative splicing. All these factors contributing to this one fundamental biological process add up to a mechanism that is critical to the proper functioning of cells. Any corruption of the process may lead to disruption of normal cellular function and the eventuality of disease. Cancer is one of those diseases, where alternative splicing may be the basis for the identification of novel diagnostic and prognostic biomarkers, as well as new strategies for therapy. Thus, an in-depth understanding of alternative splicing regulation has the potential not only to elucidate fundamental biological principles, but to provide solutions for various diseases.

引用

页码：152 / 158

页数：7

共 79 条

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