AMYGDALA KINDLING AND IMMEDIATE-EARLY GENES

被引：27

作者：

CHIASSON, BJ

DENNISON, Z

ROBERTSON, HA

机构：

[1] DALHOUSIE UNIV, DEPT PHARMACOL, HALIFAX, NS B3H 4H7, CANADA

[2] MT ALLISON UNIV, DEPT PSYCHOL, SACKVILLE, NB E0A 3C0, CANADA

来源：

MOLECULAR BRAIN RESEARCH | 1995年 / 29卷 / 01期

基金：

英国医学研究理事会;

关键词：

AFTERDISCHARGE; PIRIFORM CORTEX; PERIRHINAL CORTEX; C-FOS; EGR-1;

D O I：

10.1016/0169-328X(94)00250-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined if the first afterdischarge (AD) following a kindling stimulation to the amygdala is a necessary and/or sufficient stimulus for immediate-early gene (IEG) activation and whether activity that results in IEG expression in the amygdala was sufficient to cause activation in the hippocampus. We demonstrate that a single, short duration, AD results in activation of c-fos and egr-1 in the amygdala/piriform following a kindling stimulation to the amygdala. Conversely, considerably longer and perhaps more complex ADs are required for IEG induction in the hippocampus of amygdala kindled animals. These results suggest that a single AD is sufficient to activate c-fos and egr-1 in amygdala/piriform and establishes a putative role for IEGs in amygdala kindling.

引用

页码：191 / 199

页数：9

共 46 条

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