A LARGE MULTISITE CANCER FAMILY IS LINKED TO BRCA2

被引：55

作者：

TONIN, P

GHADIRIAN, P

PHELAN, C

LENOIR, GM

LYNCH, HT

LETENDRE, F

BELANGER, D

MONTE, M

NAROD, SA

机构：

[1] MCGILL UNIV,DEPT MED,DIV MED GENET,MONTREAL,PQ H3G 1A4,CANADA

[2] HOP HOTEL DIEU,RES CTR,EPIDEMIOL RES UNIT,MONTREAL,PQ,CANADA

[3] INT AGCY RES CANC,F-69372 LYON,FRANCE

[4] CREIGHTON UNIV,SCH MED,OMAHA,NE

[5] KAROLINSKA HOSP,DEPT CLIN GENET,S-10401 STOCKHOLM,SWEDEN

来源：

JOURNAL OF MEDICAL GENETICS | 1995年 / 32卷 / 12期

关键词：

D O I：

10.1136/jmg.32.12.982

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2 gene locus (lod=3.67 at D13S289). A number of cancers of other types occurred in this family, including three cases of prostate cancer and two cases of lymphoma. The penetrance of breast cancer among BRCA2 carriers is estimated to be 75% to the age of 70.

引用

页码：982 / 984

页数：3

共 7 条

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