MODULATION OF CARBON-MONOXIDE PRODUCTION AND ENHANCED SPATIAL-LEARNING BY TIN PROTOPORPHYRIN

被引：25

作者：

BING, O

GRUNDEMAR, L

NY, L

MOLLER, C

HEILIG, M

机构：

[1] KAROLINSKA HOSP,MAGNUS HUSS CLIN,S-17176 STOCKHOLM,SWEDEN

[2] UNIV LUND HOSP,DEPT CLIN PHARMACOL,S-22185 LUND,SWEDEN

来源：

NEUROREPORT | 1995年 / 6卷 / 10期

关键词：

CARBON MONOXIDE; LONG TERM POTENTIATION; LEARNING; MEMORY; HIPPOCAMPUS; METALLOPORPHYRINS;

D O I：

10.1097/00001756-199507100-00002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ENDOGENOUS carbon monoxide (CO), produced by haem oxygenase (HO), may play a role in hippocampal long-term potentiation (LTP). Its role in learning and memory in intact animals is less well known. Tin protoporphyrin (Sn-PP; 25 mgkg(-1), i.p.) effectively but transiently inhibited HO activity in brain homogenates, and improved acquisition in the Morris water maze. Locomotor activity was unaffected, indicating a behavioural specificity of the learning effect. The analogue zinc protoporphyrin (25 mgkg(-1), i.p.), which does not pass the blood-brain barrier, did not affect learning. If the observed memory effect is related to inhibition of HO, the role of CO in spatial learning may be different from that suggested by LTP studies.

引用

页码：1369 / 1372

页数：4

共 26 条

[11] DIFFERENTIAL REGULATION OF HEME OXYGENASE ISOZYMES BY SN-PROTOPORPHYRINS AND ZN-PROTOPORPHYRINS - POSSIBLE RELEVANCE TO SUPPRESSION OF HYPERBILIRUBINEMIA [J].