MEDIATION BY NITRIC-OXIDE OF TRH-STIMULATED, BUT NOT METOCLOPRAMIDE-STIMULATED TSH SECRETION IN HUMANS

被引:9
作者
COIRO, V
VOLPI, R
CHIODERA, P
机构
[1] Department of Internal Medicine, Istituto di Clinica Medica Generale e Terapia Medica School of Medicine, University of Parma, Parma, 43100
关键词
L-NAME; METOCLOPRAMIDE; TSH; TRH;
D O I
10.1097/00001756-199505300-00025
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
IN order to establish whether nitric oxide (NO) participates in the regulation of thyroid stimulating hormone (TSH) secretion in humans, seven normal men were treated with a placebo (normal saline) or the NO synthase inhibitor L-NAME, given at doses (40 mu g kg(-1) injected plus 50 mu g kg(-1) infused i.v.) previously found to be unable to change blood pressure. Experiments were carried out either in basal conditions or during stimulation of TSH secretion with an i.v. injection of 200 mu g thyrotropin releasing hormone (TRH) or 10 mg of the dopaminergic antagonist metoclopramide (MCP). Administration of L-NAME did not change the basal secretion of TSH or the TSH response to MCP, but significantly reduced the TSH increase induced by TRH. These data fail to provide evidence of NO involvement in regulation of basal TSH secretion. NO also appears to be without effects on the dopaminergic control of TSH secretion. In contrast, the inhibitory effect of L-NAME on TRH-induced TSH secretion suggests the mediation by NO of the TSH-releasing action of TRH.
引用
收藏
页码:1174 / 1176
页数:3
相关论文
共 39 条
[31]   BIOLOGICAL ROLES OF NITRIC-OXIDE [J].
SNYDER, SH ;
BREDT, DS .
SCIENTIFIC AMERICAN, 1992, 266 (05) :68-&
[32]   INVOLVEMENT OF NITRIC-OXIDE IN THE REGULATION OF GONADOTROPIN-RELEASING-HORMONE RELEASE FROM THE GT1-1 NEURONAL CELL-LINE [J].
SORTINO, MA ;
ALEPPO, G ;
SCAPAGNINI, U ;
CANONICO, PL .
ENDOCRINOLOGY, 1994, 134 (04) :1782-1787
[33]   IMMUNOLOGICAL DETECTION OF NITRIC-OXIDE SYNTHASE(S) IN HUMAN TISSUES USING HETEROLOGOUS ANTIBODIES SUGGESTING DIFFERENT ISOFORMS [J].
SPRINGALL, DR ;
RIVEROSMORENO, V ;
BUTTERY, L ;
SUBURO, A ;
BISHOP, AE ;
MERRETT, M ;
MONCADA, S ;
POLAK, JM .
HISTOCHEMISTRY, 1992, 98 (04) :259-266
[34]   IMMUNOHISTOCHEMISTRY OF NITRIC-OXIDE SYNTHASE DEMONSTRATES IMMUNOREACTIVE NEURONS IN SPINAL-CORD AND DORSAL-ROOT GANGLIA OF MAN AND RAT [J].
TERENGHI, G ;
RIVEROSMORENO, V ;
HUDSON, LD ;
IBRAHIM, NBN ;
POLAK, JM .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1993, 118 (01) :34-37
[35]   NEUROENDOCRINE REGULATION OF THYROTROPIN-RELEASING-HORMONE (TRH) IN THE TUBEROINFUNDIBULAR SYSTEM [J].
TONI, R ;
LECHAN, RM .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1993, 16 (09) :715-753
[36]   NEURONS THAT SAY NO [J].
VINCENT, SR ;
HOPE, BT .
TRENDS IN NEUROSCIENCES, 1992, 15 (03) :108-113
[37]   HISTOCHEMICAL MAPPING OF NITRIC-OXIDE SYNTHASE IN THE RAT-BRAIN [J].
VINCENT, SR ;
KIMURA, H .
NEUROSCIENCE, 1992, 46 (04) :755-784
[38]  
VISSER TJ, 1985, FRONT HORM RES, V14, P100
[39]   NITRIC-OXIDE MODULATES THE RELEASE OF VASOPRESSIN FROM RAT HYPOTHALAMIC EXPLANTS [J].
YASIN, S ;
COSTA, A ;
TRAINER, P ;
WINDLE, R ;
FORSLING, ML ;
GROSSMAN, A .
ENDOCRINOLOGY, 1993, 133 (03) :1466-1469