APPLICATION OF T-BUTYLDIMETHYLSILYL ETHERS OF SERINE, THREONINE AND TYROSINE IN PEPTIDE-SYNTHESIS

被引：20

作者：

FISCHER, PM

机构：

[1] Nycomed Bioreg AS, N-0371 Oslo

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)60836-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The utility of Tbdms (t-butyldimethylsilyl) ethers, prepared conveniently in a one-pot procedure from N(alpha)-Fmoc (9-fluorenylmethoxycarbonyl) and N(alpha)-Z (benzyloxycarbonyl) hydroxyamino acids, is demonstrated: peptide bond formation and esterification to 4-alkoxybenzylalcohol resin are achieved readily with these derivatives. The lability of the Tbdms ethers to various reagents enables selective deprotection of the hydroxyl side-chains after peptide chain assembly, desirable, e.g., for phosphorylation or glycosilation.

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页码：7605 / 7608

页数：4

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