X-RAY-EMISSION ANALYSIS OF HUMAN-PLASMA BY PROTON EXCITATION OF THICK SAMPLES IN AIR

被引：9

作者：

HUDA, W

BEWLEY, DK

机构：

[1] ROYAL POSTGRAD MED SCH,DEPT MED PHYS,LONDON W12 0HS,ENGLAND

[2] HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT,LONDON W12 0HS,ENGLAND

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 1979年 / 24卷 / 04期

关键词：

D O I：

10.1088/0031-9155/24/4/003

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Thick plasma samples have been irradiated in air by 2.3 MeV protons for trace elemental analysis by proton-induced X-ray emission spectroscopy. Accurate calibration curves were obtained for Fe, Zn and Sr and detection limits in dry plasma were estimated to be 0.08 PPM for Fe, 0.065 PPM for Zn and 0.12 PPM for Sr. Low temperature ashing of these samples improved the detection limits by a factor of 3 but reduced the precision and resulted in loss of bromine from the plasma. Mass absorption coefficients for low energy X-rays in dry plasma were measured and X-ray attenuation in the sample was found to prevent the detection of trace elements with Z<26. The method was used to determine Sr in plasma from a patient with bone disease, the Sr being a non-radioactive bone-seeking tracer element. The results, which were in the 3-13 PPM range, were in good general agreement with the analysis of the same samples by flame photometry.

引用

页码：711 / 720

页数：10

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