SYNTHESIS OF A DYNEMICIN-A ANALOG AND ITS BERGMAN-TYPE CYCLOAROMATIZATION

被引：34

作者：

TAKAHASHI, T ^{[1
]}

SAKAMOTO, Y ^{[1
]}

YAMADA, H ^{[1
]}

USUI, S ^{[1
]}

FUKAZAWA, Y ^{[1
]}

机构：

[1] HIROSHIMA UNIV,DEPT CHEM,HIROSHIMA 724,JAPAN

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 12期

关键词：

DYNEMICINS; ENEDIYNES; SEMIEMPIRICAL CALCULATIONS;

D O I：

10.1002/anie.199513451

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and simple approach is described here for the synthesis of enediyne 1, a model compound for the antibacterial and anticancer agent dynamicin A. Compound 1 undergoes the cycloaromatization reaction characteristic of such enediyne systems and can conceivably be attached to various “drug delivery systems” through the two ester groups. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

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页码：1345 / 1348

页数：4

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