STRAIGHTFORWARD C-8 ALKYLATION OF ADENOSINE-ANALOGS WITH TETRAALKYLTIN REAGENTS

被引：32

作者：

MAMOS, P ^{[1
]}

VANAERSCHOT, AA ^{[1
]}

WEYNS, NJ ^{[1
]}

HERDEWIJN, PA ^{[1
]}

机构：

[1] REGA INST, PHARMACEUT CHEM LAB, MINDERBROEDERSSTR 10, B-3000 LOUVAIN, BELGIUM

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)74226-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one step synthesis of the 8-methyl-, 8-ethyl -and 8-vinyl derivatives of adenosine, 2'-deoxyadenosine and 2',3'-deoxyadenosine starting from the readily available 8-bromo congeners is described. This reaction makes use of a transient silylation procedure and a Pd(0) catalysed cross-coupling with tetraorganotin reagents.

引用

页码：2413 / 2416

页数：4