3'-FLUORO-2',3'-DIDEOXY-5-CHLOROURIDINE - MOST SELECTIVE ANTI-HIV-1 AGENT AMONG A SERIES OF NEW 2'-FLUORINATED AND 3'-FLUORINATED 2',3'-DIDEOXYNUCLEOSIDE ANALOGS

被引：117

作者：

VANAERSCHOT, A ^{[1
]}

HERDEWIJN, P ^{[1
]}

BALZARINI, J ^{[1
]}

PAUWELS, R ^{[1
]}

DECLERCQ, E ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3000 LOUVAIN, BELGIUM

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 08期

关键词：

D O I：

10.1021/jm00128a013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1743 / 1749

页数：7

共 38 条

[1] BOTH 2',3'-DIDEOXYTHYMIDINE AND ITS 2',3'-UNSATURATED DERIVATIVE (2',3'-DI-DEOXYTHYMIDINENE) ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION INVITRO
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[2] SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) BY 3'-AZIDO-2',3'-DIDEOXYGUANOSINE INVITRO
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[3] 5-SUBSTITUTED 2'-DEOXYURIDINES - CORRELATION BETWEEN INHIBITION OF TUMOR-CELL GROWTH AND INHIBITION OF THYMIDINE KINASE AND THYMIDYLATE SYNTHETASE
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[4] 5-CHLORO-SUBSTITUTED DERIVATIVES OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYURIDINE, 3'-FLUORO-2',3'-DIDEOXYURIDINE AND 3'-AZIDO-2',3'-DIDEOXYURIDINE AS ANTI-HIV AGENTS
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[J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (14) : 2847 - 2856
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[9] BENNETT LL, 1984, 6TH INT ROUND TABL G
[10] SYNTHESIS, STRUCTURE, AND ANTITUMOR AND ANTIVIRAL ACTIVITIES OF A SERIES OF 5-HALOURIDINE CYCLIC 3',5'-MONOPHOSPHATES
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