EXPRESSION OF APP IN THE EARLY STAGE OF BRAIN-DAMAGE

被引：138

作者：

KAWARABAYASHI, T

SHOJI, M

HARIGAYA, Y

YAMAGUCHI, H

HIRAI, S

机构：

[1] Deparment of Neurology, Gunma University School of Medicine, Maebashi, Gunma

来源：

BRAIN RESEARCH | 1991年 / 563卷 / 1-2期

关键词：

ASTROCYTE; AMYLOID-BETA-A4 PROTEIN PRECURSOR; ALZHEIMERS DISEASE; BRAIN DAMAGE; DYSTROPHIC NEURITE; KAINIC ACID;

D O I：

10.1016/0006-8993(91)91558-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We immunocytochemically studied the expression of various epitopes of amyloid beta/A4 protein precursor (APP) after brain damage by kainic acid injection. After 3 h, APP695 rapidly accumulated in dystrophic neurites near the damaged site. After 3 days, APP with Kunitz-type protease inhibitor domain was expressed in reactive astrocytes in the lesion and ipsilateral hippocampus. APP rapidly accumulated in dystrophic neurites, and different types of APP were expressed in different cell types in the damaged brain.

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页码：334 / 338

页数：5

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